log☇︎
55700+ entries in 0.358s
phf: ah makes sense, for some reason i thought 3d printers went in the direction of spiroligomers, but hackerspace for which i was mocked is running a CRISPR project in their fridge so this is consistent
mircea_popescu: you can get bacteria to do anything you want them to ; provided you want them to do something they were going to do already. gotta be a metabolic leftover.
a111: Logged on 2017-08-28 20:30 asciilifeform: kanzure: objective was to economically make (by the kg) a (modified) butyrylcholinesterase
kanzure: you insert the reagents at the start of the reaction, the polymerase is not a permanent component of the machine.
kanzure: asciilifeform: i rescued a silly open-source nanotech cad program from being deleted and forgotten. however, i did not fund its original development. is this the thing you're tlaing about? https://github.com/kanzure/nanoengineer
asciilifeform: mircea_popescu: thermocycler is just this programmable chiller/oven item. follows a curve.
kanzure: that pic was actually taken from a volunteer birdhouse assembly workshop
asciilifeform: when you have an expense acct from usg.academia, you not only dun give a fuq what the instrument costs -- but the option of 'use peltier' is not even on the table
kanzure: asciilifeform: here's a little project of mine, recently. https://blog.kitmatic.com/2017/06/28/electroporation-is-now-quick-high-yield-and-commodity-priced/
asciilifeform: i remember the first time i used a pcr thermocycler and was told 'costs 8k usd', and thought 'are you all retarded, peltier on my cpu cost 10bux'
mircea_popescu: kanzure " Obviously there is no possiblity of meaning outside of a structure of authority, and the authority can not be predicated on the meaning." ☟︎☟︎☟︎☟︎☟︎☟︎☟︎☟︎☟︎☟︎
kanzure: asciilifeform: insufficient money i think. although this might be a bad reason. i could accept that. nobody calls me on this type of thing.
asciilifeform: i'll even buy a ticket to watch.
mircea_popescu: take a more productive tack, like say something concrete.
mircea_popescu: well, actually, i'm the authority here, definitionally what i'm saying can't be babbling. you've upgraded your argument from "your intel is broken" to tmsr dun werk, it's a very dubious trek.
kanzure: certain things are more feasible than others. and there's a lot of morons out there causing lots of noise.
asciilifeform: http://btcbase.org/log/2017-08-28#1704198 << there do exist known single-locus items. just as 'flip this byte to nop and removes the derpy copyprotection' was a thing in manmade items. ☝︎
asciilifeform: so logical -- a la 'dumpster', 'xerox'.
a111: Logged on 2017-08-28 22:42 mircea_popescu: in other lulz, here asciilifeform i got one for you : drujba in romanian ? chainsaw. and because there was that whole 80s "ask a girl for her friendship" thingee, ... "he offered me his chainsaw".
kanzure: is that a broad wlfare of survitude to wealthy patrons or what
kanzure: i read a bunch though: http://diyhpl.us/~bryan/papers2/bio/ http://diyhpl.us/~bryan/papers2/DNA/ http://diyhpl.us/~bryan/papers2/neuro/ etc
mircea_popescu: anyway. are you pursuing a microbiology phd or something kanzure ?
kanzure: i should not claim to be related to the codon recoding, it's a subproject that was not proposed by me
phf: i don't think so, this is more like figuring out that something's broken in a car by the sounds that the engine is making. doesn't mean that the car's not working anymore. it seems reasonable though that causes and purposes would be the response, since that kind of eliadism is a natural counterpoint to above... that's just my impressions though
mircea_popescu: consider a simple element of historical warfare, that the us army could not reproduce today : arrow messaging. now, what is the effect of forest guard locus #48 on the court getting news of battle at hartford ? toggle it to what, taller man ?
mircea_popescu: in other lulz, here asciilifeform i got one for you : drujba in romanian ? chainsaw. and because there was that whole 80s "ask a girl for her friendship" thingee, ... "he offered me his chainsaw". ☟︎
phf: "intelligence" "humans are idiots" "kurzweil" "working memory" "genetics" "yudkowsky". it's funny at some point you don't even need to read the log, you can figure out the particular, previously observed failure mode of a person by keywords that stand out
trinque: no sort of political labeling *of reality* is going on, only labeling of a particular failure mode of the mind.
kanzure: apparently it would be invalid. but not if it's labeled a cause. that's my understanding of the feedback so far.
trinque: what'd it mean if it were a purpose?
kanzure: but it can't be a purpose? okay.
trinque: isn't it rather that in observing your own ignorance on a subject, you were moved to appear here?
trinque: that was in no way a response to my question, and this isn't "lets all shitpost our feelings to signal how smart we are"
kanzure: 15:10 < kanzure> i'm a little confused. i know the prepwork is really annoying and laborious in theory. perhaps he should just mean a low-effort nuke.
kanzure: 'Someone, somewhere, may well possess the secret of how to build a thermonuke using the materials of ordinary electronics.' *cough*
mircea_popescu: someone needs a new eyboard.
mircea_popescu: http://trilema.com/2014/pushing-the-soft-tender-flesh-of-a-friend-against-the-sharp-rotating-blades-of-the-immutable-machine/#selection-959.491-969.11 << satan paying you to love him reference.
mircea_popescu: does the sun also come out for a reason ?
kanzure: "I don't want anything, it's a factual observation." <-- this person is lying. he was communicating for a reason.
kanzure: alright well anyway, discipline seems more like a reliable metric i suppose, but go back to your insistence on causes not outcomes
kanzure: is swinging a hammer a form of effort here? i don't know man.
kanzure: could be anywhere from zero to a lot of effort, if they made no progress. but they might also be idiots.
mircea_popescu: the pro got there, tore it all down without breaking a sweat.
mircea_popescu: anyway. he'd hire student kids to do work for him. i once watched a dozen of them, try to demolish a wall with a 60kg hammer.
mircea_popescu: kanzure when i was a kid, i had a friend. he built this shambling abomination of a bar, each layer a different style, floor after floor.
mircea_popescu: "memory", what's that. he got a bit of memory out of his own body through structuring the environment.
mircea_popescu: asciilifeform i subscribe, not a bad angle. in fact, possibly best available atm.
mircea_popescu: in any case ; i am notorious for a very poor memory, including complete inability to remember say actresses names. ☟︎
asciilifeform: kanzure ^ somewhere in there, we had a testable hypothesis.
a111: Logged on 2016-12-21 18:32 mircea_popescu: because no, words don't "have meanings". your meanings for ANY WORD are a function of ALL THE OTHER WORDS YOU KNOW. which is why my definitions regularily blow out english dictionaries, wikipedia and other sources of "wisdom" out of the water - i know more words, and in this knowledge i know all the words i know ~better~. infinitely and irreproducibly so.
mircea_popescu: we never had a good outing of this theme ; but it is my (probably heretical) notion that memory size dun really enter into it.
kanzure: the difference between a monkey and a human is interesting. the difference between human and human, as measured by iq, is totally irrelevant to me. humans are idiots if you compare them only to each other.
mircea_popescu: or am i expected to think "designer" isn't to be interpreted to mean i can want a smart baby ? after all i can buy designer bags, of whichever kind, the only bags i can't buy being bags that ARE ANY GOOD. something like that ?
a111: Logged on 2017-08-28 20:20 kanzure: well in many cases the mutations listed on that page have not been documented (on that page) as impacting positively or negatively. so the document should not be considered a definitive lookup table.
mircea_popescu: http://btcbase.org/log/2017-08-28#1703847 << let's have a look at what "Documenting" would look like on a topic of interest (intelligence) : http://trilema.com/2015/the-genetics-of-intelligence/ ☝︎
mircea_popescu: you know, dude was a better napoleon in the sense the term's usually used. he certainly didn'\t fucking forget about a whole army corps etc.
mircea_popescu: there isn't a "for every million clay pots you get another one of the 17 symmetries". the right guys need twenty pots to find all of them. the polynesians or the africans will NEVER find them like they never found fucking madagascar.
mircea_popescu: asciilifeform give him a reprieve wouldja ?
asciilifeform: http://trilema.com/2014/fata-morgana-or-the-mirage-of-a-free-and-open-market/ << mircea_popescu
a111: Logged on 2016-11-07 16:53 mircea_popescu: recall the "where are the rembrandts then" argument ? the us fails to produce a philosopher worth the mention every other decade ; athens managed that much on 1/1000th the population.
mircea_popescu: a well.
mircea_popescu: o ? is this the guy who brave brave brave sir robert put out a fanfic challenge, then trilema blew a hole in his head and he "never heard of it" a la buffett ?
asciilifeform: BingoBoingo: thiel's catamite. he even bought him a harem, so he can pretend 'just like mp!'
mircea_popescu: discipline is a narrower set than effort, you understand. it seems "hard" ie efortful, especially for the noob. but it is not that hard once you internalize it. the effort-seeker howevere ends up mired in your sort of activity, "what's the most mentally painful activity, that'll be REALLY putting in some effort".
mircea_popescu: and yes there's some relation between discipline as a societal construct, and politics. but this is complicated and poorly understood.
asciilifeform: kanzure: civ1 lied to you: there ain't such a thing as a 'money to discovery converter' you can shovel freshly-printed benjies into, and get transgenic mighty man out
mircea_popescu: kanzure my survey of the online world mostly happens in the sense intel prepares summaries which i sometimes read, but generally looking for a laugh.
BingoBoingo: <kanzure> you know maaku's apoliticalism right? << BWAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHHAHAHAHAHAHAH A clash of who remembers/knows who with predictabru results
asciilifeform never once heard of a maaku
mircea_popescu: (i have a very deep dislike for modern derps putting their name on things, though.)
kanzure: nah no links. he just has a deep hatred of politics.
kanzure: i would argue there is a knowledge component.
mircea_popescu: the thing where getting a "designer baby" be 99.9999% identical to an actual baby makes it less tolerable than a 99% or 80% similar result ; and not a little less tolerable, EXTREMELY intolerable.
mircea_popescu: this is a problem.
mircea_popescu: it's plants which have been selected for the only hopefully-economically-useful trait available. which is already a very distant push.
kanzure: my technique of favor at the moment is inkjet-based synthesis, a writeup is here but it's a well-known technique http://diyhpl.us/wiki/dna/synthesis/notes/
mircea_popescu: so effort was instead moved to plants, which are three degrees of magnitude simpler. there, the approach works, you blast a square mile worth of soy with random nonsense and then select the few plants still standing. which is how the whole "glycosate-resistent" craze started : it's not DESIGNER plants.
mircea_popescu: so, originally genetic experiments were carried out on mammals, hence dolly the cloned sheep. it rapidly became obvious that the only available tech ("throw shit at wall, maybe something sticks") is a terrible fit for the complexity of mammals, and there's absolutely no hope of obtaining iondustrially usable results this generation there.
mircea_popescu: sigh. alright, here, let me give you a primer on genetics as a tehcnological consideration, so you can impress the "what happened to mp" ass-up-buttholes with your transcendental scholarship.
BingoBoingo: mircea_popescu: Never had the cabbage juice. Twas a big fan of curing hangovers with moar booze
mircea_popescu: BingoBoingo the way you make this is that in a dry and cold cellar you emplace a tun, 100 liters say. then fill it with whole cabbages. then add brine and some spices. then let it sit a few months.
kanzure: and the controversy stuff is a tacky add-on, i'll admit.
kanzure: mircea_popescu: i disagree with your evaluation of whether it's a waste of time, or that it is fashionable in the least. i simply recognize the value of controversy.
mircea_popescu: it gets to a ~functioning~ model for designer babies.
mircea_popescu: kanzure the model whereby you "attract funding" for "your idea" is fundamentally broken. i don't mean a little broken, i mean fundamentally broken -- it makes it impossible to actually have an idea, which is why your "attempt to find the most controversial conceivable notion" ended up with "what bit of fashionable nonsense could i waste my life with in the optimisitc but ultimately baseless hope it'll be worthy my or anyone's
kanzure: it's hell of a way to spend one's life, that's all.
kanzure: asciilifeform: i have someone else working on a very similar project these days. it's in progress.
mircea_popescu: really, "i wonder what happened to the clouds, i've not been out of basement for a decade, poor clouds, they must be faring poorly"
a111: Logged on 2017-08-28 16:16 asciilifeform: shinohai: 'What's the latest on Mircea? I've not heard about him in a while.' 'I think his followers actually kind of excommunicated him after he lost their bitcoins. I don't pay much attention to them though.' << didjaknow !
mircea_popescu: THIS is what your money's fucking buying omfg, "i live in the country so i can spend 80k a year on renting a cardboard box and have nice coasters which are worse than a fucking pile of dried goat shit"
kanzure: about to get unvoiced i think. could someone offer mircea_popescu a link to the right place in the logs for the eugenics war.
mircea_popescu: here's the problems with "expensive, upscale" coasters : they're not a square of cut up cork, like you'd expect if they were you know, uncivilised, unglamorous, un-internet-of-things orcfare. no. they're a thin strip of cork glued to cardboard with some shiny drawings on top. ☟︎
mircea_popescu: i guess. there's an inch of soil and under that basalt, you understand. there's a reason jungle soil is poor -- all of it gets washed into ocean.
mircea_popescu: shinohai if i lived in a jivilized country with jews in it i'd just have some cabbage juice. sadly, no cellars here. too hot, too wet.
shinohai recommends 2 excederin and a bottle or 3 of Gatorade ....
kanzure: first you have to kill everyone who has ever had a headache...
mircea_popescu: i got a fucking headache.
asciilifeform: ( this is in the l0gz somewhere, ancient thread , if you give a damn )
asciilifeform: kanzure: objective was to economically make (by the kg) a (modified) butyrylcholinesterase ☟︎
kanzure: http://diyhpl.us/wiki/transcripts/hgp-write/2016-05-10/synthesizing-a-prototrophic-human-genome/