557700+ entries in 0.347s
BingoBoingo: Right.
Teixobactin prolly isn't going
to get used much orally aside from GI
tract stuff like c Diff... If it
targets c Diff at all.
gribble: Error:
The answer exceeded 1.79769313486e+308 or so.
BingoBoingo: Yeah. Lighter
than Vancomycin's 1449 as a further illustration of
the sheer size of
the space.
BingoBoingo: And why
the distributed protein folding stuff is mostly a noisemaking lottery machine.
mircea_popescu: here are not enough resources on Earth, or in our entire solar system,
to do enough organic synthesis
to make any noticeable dent in
that array.
The idea of having compounds
that bind
to
things like Lipid II is a good one, but
they're going
to have
to be large compounds, and exploring
that space is daunting.
mircea_popescu: As an aside, if you're outside
the field, you might wonder why it's worth working so hard
to find natural products when we have so many synthetic organic chemists in
the world cranking out new compounds. One big reason is
the ridiculous, insane hugeness of chemical space:
the number of possible compounds at or under
the molecular weight of
teixobactin defies description, and I mean
that in a completely literal sense.
T BingoBoingo: I mean
the past century has mostly been about refining
tools while methods for using
tools atrophied. A lot of potential in just... pointing
those
tools somethere else in an informed way instead of doing
the microscope hammer
thing.
mircea_popescu: i am
telling you, wetware before any hard physics breakthrough.
mircea_popescu: as
the guy aptly points out, it's never been a better
time
to be a biochemist.
BingoBoingo: Who woulda
thunk
there's be worthwhile shit in stuff
that doesn't culture as cheaply as possible?
mircea_popescu: ah.
there's a fine reason
to prefer women. if well
trained... hard
to match.
BingoBoingo: That dedication
to
task which he can't get from his acolytpes
BingoBoingo: I honestly don't know what can scare Obama more
than
that.
mircea_popescu: btw,
the vomit
thing actually happened. girl had
to eat catfood, out of bowl, no hands. long hair, one hair ended up in
there, she had
to eat it, it made her puke, she had
to eat
that, which she did. one strange half hour.
gabriel_laddel: Me: "so what do you
think of MPEX"? He: "What
they do is illegal!! You can't
take money from investors in
the united states without explicit approval of USG!"
gabriel_laddel: Etherum guy
tells me
that he wants a "Holarchy" instead of an explicit hierarchy cause
trilema articles are scary.
gabriel_laddel: Har, remembering: Girl
tells me she wants
to crowdfund art. I link
to
trilema.com/what-is-art? She never responds.
BingoBoingo: How else did Rome handle
the vomit problem?
gabriel_laddel: people fucking flip over slaves licking up
their own vomit.
gabriel_laddel: some of
the luzly ones read... re-read... re-read and eventually ask "Does he hate women or...?" (Not rabbits article)
gabriel_laddel: mircea_popescu:
this is how I know
they've not read it. I
tell
them it is Romanian and pull up google
translate in another
tab, show
them
the keybinding
to switch
tabs.
mircea_popescu: gabriel_laddel wait, wasn't
the rabbit article in romanian ? what're
they
to read ?!
undata: due
to
the random article upon loading
the homepage I am careful where I pull up
trilema
gabriel_laddel: lol.
twould be more entertaining
than all of
the bezzle 'media' output circa 2014
mircea_popescu: i guess at some point it'll come
to pass
that someone makes a
tumblr,
TFWT.
gabriel_laddel: I
think, all of
the sudden
they understand on some level
that
this era of prosperous morons is coming
to a close.
gabriel_laddel: I've shown several people in Silly Con valley
the rabits article. Fear flashes
through
their eyes and
they hand
the laptop back without reading it all
the way
through.
BingoBoingo: Yeah. Also
there any number of poisonous alcohols more similar
to various sugars
than ethanol.
BingoBoingo: Of course, and many of
those are almost sugars.
BingoBoingo: sweet is probably common in poisons because of
the large class of poisons
that are almost biologically useful...
assbot: Logged on 22-08-2014 02:36:18; asciilifeform: 'The smell of diborane is known
to a few experimenters, but
they cannot
tell us what it is.'
mircea_popescu: bioaccumulation (heavy metals, etc) is much more a concern for fish eating
than otherwise.
BingoBoingo: Restaurant wants
to milk every seat for max profit.
BingoBoingo: Reviewer wants
to get full on
their per diem
BingoBoingo: <mircea_popescu> i dunno, something about oversalted leberwurst. << Also
the shift from a menu one can get full eating
to some sort of "trendy"
tasting menu based on appetizers.
mircea_popescu: “All of us at
The Inn at Little Washington have much
to be grateful for as we enter
the new year.
The Inn remains
the longest-tenured Forbes Five Star and AAA Five Diamond restaurant in America. We possess
the highest Zagat rating (29, 29, 29) in
the world. Once again,
The Inn has received
The Washington Post’s highest 4-star rating from restaurant reviewer
Tom Sietsema. Most of us understand
that, in
today’s wor
assbot: Chef Patrick O'Connell Questions Washingtonian's Ethics for Demoting
the Inn at Little Washington | In
the Magazine | Washingtonian ... (
http://bit.ly/1ADbL10 )
artifexd: One more question: Any objection
to adding a
timestamp
to
the
trust ratings in gossipd?
mircea_popescu: they';re so common i'm persuaded a good fraction of local women actually go about
the house in
those
things.
mircea_popescu: by
the way : pretty much every kitchen shop here has, along
the pots and pans, kitchen aprons.
mircea_popescu: hide
the clitoral hoods, abscond
the mounds, science is on
the field!
assbot: Logged on 29-10-2014 01:36:30; asciilifeform: everything feels free
to manipulate
the hanging bits
mircea_popescu: yeah html hates < separators. but for some reason
they seem
the best way
to convey
the intent here
artifexd: Tip
to future copy/pasters: Don't include << in
the
text or everything after it will get routed
to /dev/null
mircea_popescu: ends in "mircea_popescu: sure".
that seems right neh ?
mircea_popescu: i always liked
the "fuck you,
they're strings, and concatenation is
the only operation" approach.
BingoBoingo: Maybe just a compulsive reloader? Perhaps some derp was serving one of our pages in
their iframe?
mircea_popescu: BingoBoingo i dunno, but it's a bw depletion rather
than
the prev ram/cpu/state depletion. doesn't seem
to have done anything.
mats: fun fact:
the python stdlib had an enigma implementation
til 2.4
mircea_popescu: seems you're shoehorning
the filesystem into it instead ?
artifexd: I am currently using pointers
to exported key files instead of
trying
to shoehorn keys into config files.
artifexd: What is
the format of said document?
ben_vulpes: me i'm just fascinated
that
the savages can bang such arms
together with basalt and obsidian
mircea_popescu: let A connect
to B. let A pass a message
to B in
the format "A for X, sup". B must find in
the hello message
through which A connected
to it a document where X signs A's privkey,
ben_vulpes: asciilifeform: consider it an otherwise unremarkable arrowhead from
the dig
artifexd: All
the words make sense but when you put
them in
that order...
artifexd: mircea_popescu: can you elaborate on "a pgp-signed document by
the for key certifying
the validity of
the IPs public key with an expiration unixtimev in case
the for field differs and a nickname"?
ben_vulpes: in
the game of retarded
telephone
that is
the us link reposting scam masquerading as 'nooz'