717500+ entries in 0.435s
BingoBoingo: I have an admitedly odd neurology. I
throw a baseball right handed but have
to shoot
the rifle left handed.
BingoBoingo: Parkinsons is more a D-1 and D-3
thing
though.
BingoBoingo: I guess because
the gene was
TAQ something or other
BingoBoingo: asciilifeform: Back when 23andme made medical declarations I spit in a
tube. Apparently I am part A-Rab
mircea_popescu: anyway. i'm kinda up
to here with
the smoking addiction
thing. i've been smoking since ~16.
that's
two decades ago. i still smoke, i average a pack a month. prolly less
these days. it
takes all
the willpower of a
tomato as far as i can
tell, it's never bothered me.
BingoBoingo: Keep in mind my experiences prolly don't map onto
to many others. I'm missing 1/2
to 3/4
the D2 receptors most people have in
the general population)
BingoBoingo: Over 15lbs even, if we are going arbitrary and 16 hours, 5-15 lbs,
The unpredictability of load has value.
BingoBoingo: 16 hours of lifting arbitrary
things about nicotine cessation for
the habituated
mircea_popescu: after six weeks of
that,
the choice is never smoke again and never have
to crate it up again
BingoBoingo: Well, you have
to consider what receptor is involved at
the intersection of skeletal muscle and
the neuro
mircea_popescu: get a special bed rigged where you get pricked with a pin. all
the
time. somewhere.
mircea_popescu: now
that's an inconvenience. not fucking nicotine deprivation.
mircea_popescu: do an experiment where you get shocked at a modest 48 volts at random intervals on average 8
times a second.
mircea_popescu: people just conveniently pretend like
their experiences matter out of all proportion.
BingoBoingo: mircea_popescu: In
the accultured. As opposed
to
the occasional
mircea_popescu: it raises
the most minor of inconveniences conceivable.
BingoBoingo: Nicotine is
the perfect model of an addictive drug because
tremendous excess is
tolerated by
the peripheral neurons, but its absence after
tolerance raises holy fucking hell.
BingoBoingo: With L-Dopa
the Blood Brain Barrier plays a role, but convulsions play a bigger one
BingoBoingo: asciilifeform: And I sat
through literally 2/3rds of
the PharmD curiculumn, half of it
twice. But as a
TA so I get no credit for having done such a
thing.
BingoBoingo: If dopamine for its own sake was
the desired effect, junkies would skip heroin and just eat L-DOPA and broadbreans
mircea_popescu: and i'm not gonna give stan any more credit
than i gave benkay either
BingoBoingo: And of
the major addictive drugs of abuse only cocaine and amphetamines hit any
type of dopamine receptor primarily
mircea_popescu: dude i love
this chan. i shall now write yet another great
trilema article on
the basis of shit i ran into here.
BingoBoingo: There are different dopamine agonists and antagonists
that don't all hit
the same
types of dopamine receptors
BingoBoingo: Well,
think of dopamine (which
the pharmacologically illerterate posit fuels all addiction)
BingoBoingo: And
the literature reveals nicotine excites some, but not all cholinergic receptors.
BingoBoingo: Works on its own subset of
the acetycholine responsive system while ignoring others.
BingoBoingo: The only big error with
the link is
that nicotine is not *cholinergic* at all
mircea_popescu: "If you /are/
the majority and I am in
the minority, how could you possibly believe
that I have not already and many years ago figured out exactly how you guys work? If you had
the brain
to do it,
this would be a grave insult, but you do not
think ahead. You do in fact not
think at all, because
the
things you say can only be uttered by a mind closed shut long ago."
BingoBoingo: asciilifeform: Your link on nootropics reminds me of why
the alcohol/caffine combination is my prefered and only regular combination from
that
toolset.
BingoBoingo: Pine
tar is spiking
the plane (The F-16, a wily old pitcher) amphetamine is spiking
the pilot (B-2 crews, Barry Bonds)
BingoBoingo: Of course. It is better
though if both
the pilot and plane are spiked.
mircea_popescu: BingoBoingo but
the one
thing
that makes
the plane "more responsive" is spiking
the pilot.
BingoBoingo: Well afterburners is amphetamine. Pine
tar is whatever makes a plane more responsive, engineered instability or whatever
mircea_popescu: afterburners are a pain in most situations
tho. much less precision
BingoBoingo: asciilifeform: Or rocket with boosters.
The sauce only provides benefits for so long.
BingoBoingo: mircea_popescu: Pine
tar. So
the sticky stuff pine leaks basically. Batters use it
to not
throw
the bat into
the crowd. Pitchers use it
to add precision
to
the point
they release
the ball.
BingoBoingo: mircea_popescu: And
this is baseball so
there are nearly as many balls spent in
the game as outs.
BingoBoingo: mircea_popescu: It affects grip and
the aerodynamics of
the ball.
BingoBoingo: It was rumored
that in baseball clubhouses leaded vs. unleaded was how
they refered
to amphetamine spiked coffee
ThickAsThieves: lol forumite says
to me "What would it possibly
take for you
to remove
the negative
trust you left me?"
mircea_popescu: cazalla well, if he had or hadn't, still has
to be in bet interval. wasn't like a "first
time" or anything
BingoBoingo: But
the distinction between leaded and unleaded coffee isn't caffinated vs. decaf.
mircea_popescu: the se;f confidence
thing sounds just like greenspun's problem
BingoBoingo: And is
the reason many high level players don't want
to see olympic chess.
BingoBoingo: (This sidesteps
the part where all of
the good batters have ADHD diagnoses because amphetamines are
the best performance enhancer for a batter)
ThickAsThieves: has anyone done useful research about pitching with
tar?
BingoBoingo: Basically
there are reasons it is mostly aging hitters
taking steroids, but every pitcher is doctoring
the ball.
BingoBoingo: Steroids do little in baseball beyond decreasing
the
time
to recover from injury and maybe adding a bit of power. Doctoring a ball
though is nearly essential for a pitcher
to excel.
ThickAsThieves: pitchers argue its only
to prevent
totally losing
the ball into
ttghe crowd
BingoBoingo: asciilifeform: Different from steroids in
that
the results are more quantifiable.
BingoBoingo: asciilifeform: It's use is necessary
to master
the craft, but exposing it is a faux pas.
ThickAsThieves: basically people are superstitious
that picthers can do magical
things when using
tar
BingoBoingo: asciilifeform:
Tar for pitchers is considered a forbiden necessity. For batters it is completely acceptable.
ThickAsThieves: as in,
they obv cant
totally stop people from using it
BingoBoingo: I mean
the writer cam
to
the wrong conclusion. It should still stay "banned" but discretion is
the first step
towards sophistication.
ThickAsThieves: "Totally agree
that it should be legal. In
the mean
time, Pineda really just needs
to get better at
this. I mean, he should realize
that he is being watched after
the last incident,
there has
to be a better place
to put pine
tar
than on your neck. Just learn
to cheat better."