682600+ entries in 0.466s
BingoBoingo: That is
true. Microbes generally don't
try
to kill other microbes
through folate
though.
mircea_popescu: BingoBoingo meant
the agricultural/synthetic
thing a reference
to an earlier discussion about how industry and agriculture compete for financing. you prolly recall it
mircea_popescu: (their only limiting factor is
that human cells don't have a defense either, and rarely do you get a bonanza like
tpi
that's 5k as afine
to bacteria folic process as
to human for unknown reasons)
mircea_popescu: the sort
that we've obtained synthetically, however, generally have no defense.
mircea_popescu: and yeah, some plasmids exist for circumventing some antibiotics,
the sort
that we've obtained "agriculturally" so
to speak.
BingoBoingo: Most routes
to drug resistance encountered so far have been a round a long
time, because some population of bacteria in a species need
the genes
to survive. Bacteria don't just spread genes
through reproduction
though... Microbiology is like Bioshock. Staph can pick up a plasid and get superpowers.
mircea_popescu: ThickAsThieves assuming it loads. i'm
two seconds in here.
assbot: NBC News - Breaking News &
Top Stories - Latest World, US & Local News
mircea_popescu: so
the pre-existing defense
theory doesn't really hold as well as all
that.
mircea_popescu: in principle bacteria would have as good a chance
to develop immunity
to
tpi as it would
to penicillin.
they're both antibiotics (granted, one static,
the other cidal, whatever)
ThickAsThieves: i dont
think
there's a right or wrong, all
the variation in question is needed
BingoBoingo: Thus adapting
to old age and celibacy is hard.
BingoBoingo: Other bacteria
though
tend not
to have
the luxury of waiting
that long when
they engage in chemical warfare.
BingoBoingo: mircea_popescu: Well, in a human body's environment a bacterium doesn't have long before it needs
to fuck itself and reproduce or die.
mircea_popescu: the only way bacteria meaningfully exists from an evolutionary standpoint is
that it passes itself on
ThickAsThieves: ''I saved for 45 years … It was my carer's pension and his disability pension,'' said
the Sydney retiree.
BingoBoingo: mircea_popescu:
The distinction is -cidal actually kills
the bacteria. -static keeps
them from reproducing long enough
to have enough die of old age or allow your immune system
to catch up. When it comes
to adpatation and resistance it matters quite a bit.
mircea_popescu: BingoBoingo perhaps on
the grounds of my ignorance, i see little value in
the bacteriostatic / bactericide distinction
BingoBoingo: mircea_popescu:
Trimethoprim is great in
the way Sulfa antibiotics and doxycycline are great.
They are merely bateriostatic agents. Combine
the right bacteriostatic agents and you might actually kill some bacteria. Mostly
though bacteria aren't adapted
to combinations of
them and it might
take centuries for Bactrims list of vulnerable organisms
to
thing appreciably.
bitcoinpete: research
that sorta didn't really make it
to
the west after
the fall
bitcoinpete: i remember reading about russian/soviet research into
them
BingoBoingo: asciilifeform: Phages are probably
the only long
term solution.
mircea_popescu: BingoBoingo
this is approximately correct, especially if you focus on
things such as penycilin. not quite as
true with substances such as say
trimetoprim
mircea_popescu: i guess
their victory was of such resounding nature in
that battle
that now hsbc is doing it
BingoBoingo: mircea_popescu: Well,
the reason we've found any substanital antibiotic
this far is because some other microbe produced it as a defense and before we produce
the chemical on an industrial scale,
there are minority bacterial populations carrying genes for resistance.
ThickAsThieves: "HSBC is one of
the leading international banks.
Technology plays a big part of
the banking world nowadays.
The advent of mobile devices, bitcoin, crypto currency, access
to internet, are change everyday banking. Create a position paper on
the benefits of Bitcoin being adopted and being a part of HSBC consumer products. Pick a position in favour or against and please add your sources."
assbot: The answer lies in
the sewers - Pastebin.com
mircea_popescu: nevertheless,
their deployment in practice does not (a state of affairs asciilifeform periodically protests with a parachute example)
mircea_popescu: think in
the following
terms :
the
tools mpex will use any
to defeat any attempt at enacting a sovereignity claim superior
to its own certainly predate any such claims
mircea_popescu: while
the plasmids may actually predate it,
their use likely does not.
BingoBoingo: I'm
trying
to
think what would even be a close second...
BingoBoingo: Aspergillius is probably my favorite pathogen because it is a huge fuck you
to stoners
thinking
they are all high and mighty because
their weed is "safer"
than my booze.
BingoBoingo: Note
that broad spectrum antimicrobials
that maintain effectiveness over
time
tend
to be merely bacteriostatic and not actively bacteriocidal...
BingoBoingo: Well,
the plasmids necessary for S. Aureus
to become Beta Lactam resistant and Enterococcus
to become Vancomycin resistant predate our harnessing either
therapeutically...
mircea_popescu: still an open question as
to how much iathrogenic pathogen virulence is due
to you know... better hospital
techniques.
BingoBoingo: mircea_popescu: Or for Candida
to accelerate
the way Y. Pestis did...
mircea_popescu: BingoBoingo for all you know, a world without listeria is
the prerequisite for a better strain of herpes
BingoBoingo: mircea_popescu: Pretty horrible I imagine, but probably even less possible
than
than impassible
task of eradicating Herpes.
mircea_popescu: BingoBoingo i wonder what
the ecological impact of listeria's disappearance would be like.
assbot: New sensor
to detect food-borne bacteria on site
mircea_popescu: if he had a few slaves around
the house whose lives and physical integrity depended on his good humour, he wouldn't find himself ossified in
this form of compensatory idiocy.
mircea_popescu: these are
the hidden costs of " welfarism" :
that in order for its pretense
to be maintained,
the actuality of a caustic environment for
the natural needs of
the superior has
to be enacted.
mircea_popescu: it is, but only because of
the poisonous enviroment in which
their socialist conationals soak
them.
mircea_popescu: this is how people like me end up when
they're 50, if
they don't have
the sense
to bdsm etc
mircea_popescu: that's not even
the objection. if you read his contributions in his own comment
thread above,
assbot: Mouse Practice - Wikipedia,
the free encyclopedia
assbot: How
to fail -
the Scott Locklin method. pe
Trilema - Un blog de Mircea Popescu.
BingoBoingo: There's more painful exercises in attempting
to learn a programming language. In 6th grade I
tried
to learn Perl with pencils and paper...
punkman: mircea_popescu: I don't hate it per se, but I'd rather avoid
that learning curve for now
mircea_popescu: Those issues may be avoidable, but only at
the cost of additional atomic instructions on both
the read and write ends, which would significantly impair
the performance." <<
this guy is a prime example of what i said of finance
types being
tech clueless.
mircea_popescu: 2) You can’t
tell when a reader is currently processing
that
tick, which means you could potentially write over
the prior record when he has only read part of it, making
the
tick inconsistent (which is also bad).
mircea_popescu: 1) You can’t
tell when a reader has already progressed past
that
tick, and would
thus miss your update (which is bad)
mircea_popescu: "You will probably find
that approach unworkable in a Disruptor style queue for market data because:
mircea_popescu: asciilifeform recall
the one
time
their excel copula calculation failed spectacularly and
the whole firm went under because of it ? no arse was harmed.
punkman: asciilifeform: could you recommend a lisp for
this lisp-deficient noob? (and maybe an IDE
that's not emacs)
mircea_popescu: if you run into a wall street dude hitting on a cocktail waitress, it's probable she groks more of grep
than him.
mircea_popescu: finance
types are possibly
the most
tech-clueless people you'll ever meet.
mircea_popescu: "Speaking as an insider, I can
tell you
that most HFT firms playing around with FPGAs are doing so because of slick-talking FPGA marketing hucksters.
The more
that perverse incentives change,
the more
they stay
the same" << flanagan has a point.
mircea_popescu: yes, at which point i prolly observed
that it's a
technologee current bitcoin miners don't got.
BingoBoingo: asciilifeform: I played with Singularity a bit when it was fresh.
The "respectability farm" is
the impression I got.
mircea_popescu: "Go with a straight-dataflow paradigm, where all operations are part of a dependency graph (and if your chip is large enough, exist at all
times as physical objects which wait for
their inputs
to become available, and signal
their successors within picoseconds of
their output becoming ready.)" <<
tbh,
this is not only grand in
theory
BingoBoingo: asciilifeform: I remember
that last
time you dropped
that link and
the doubters in
the
thread, but now... If even Microsoft can pull off FPGA acceleration...
BingoBoingo: punkman: As I play with it I'll prolly
think of
things
BingoBoingo: punkman: Not
that I can
think of atm. Numbers
tend
to influence how much I bet rather
than whether I bet in
the first place.
fluffypony: BingoBoingo:
the same
thought occurred
to me
assbot: Microsoft Catapults geriatric Moore's Law from CERTAIN DEATH
The Register
punkman: BingoBoingo: will publish source soon, any ideas for extended bet analysis or other
tools?
BingoBoingo: mircea_popescu: Got
two one pound packages still hot for $3.50, I love passing
through
the middle of nowhere.
mircea_popescu: just how amusing it'll fail is up
to circumstance, but yeah.
mircea_popescu: but basically yeah,
there's names which serve as marks of failure. something with goat involved, or nefario, or preston byrne or
taaki etc can only fail
BingoBoingo: mircea_popescu: no, we're intelligent housewives, not dumb american housewives. << I had a disappointing lapse into Americanisms
today. I
timed my return drive poorly and passed
the restaurants before
they opened. Ended up getting fried chicken livers at
the supermarket and eating
them as I drove
the rest of
the way back.